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Synchrotron X‐Ray Fluorescence Nanoprobe Reveals Target Sites for Organo‐Osmium Complex in Human Ovarian Cancer Cells

25 Dec 2016

Abstract excerpt

Abstract A variety of transition metal complexes exhibit anticancer activity, but their target sites in cells need to be identified and mechanisms of action elucidated. Here, it was found that the sub‐cellular distribution of [Os(η6‐p‐cym)(Azpy‐NMe2)I]+ (p‐cym=p‐cymene, Azpy‐NMe2=2‐(p‐[dimethylamino]phenylazo)pyridine) (1), a promising drug candidate, can be mapped in human ovarian cancer cells at pharmacological...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 28012260
DOI: 10.1002/chem.201605911

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