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Platinum iodido drugs show potential anti-tumor activity, affecting cancer cell metabolism and inducing ROS and senescence in gastrointestinal cancer cells

22 Mar 2024

Abstract excerpt

Abstract Cisplatin-based chemotherapy has associated clinical disadvantages, such as high toxicity and resistance. Thus, the development of new antitumor metallodrugs able to overcome different clinical barriers is a public healthcare priority. Here, we studied the mechanism of action of the isomers trans and cis -[PtI 2 (isopropylamine) 2 ] (I5 and I6, respectively) against gastrointestinal cancer cells. We...

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PMID: 38519773
DOI: 10.1038/s42003-024-06052-5

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