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Metformin reveals a mitochondrial copper addiction of mesenchymal cancer cells

6 Nov 2018

Abstract excerpt

The clinically approved drug metformin has been shown to selectively kill persister cancer cells through mechanisms that are not fully understood. To provide further mechanistic insights, we developed a drug surrogate that phenocopies metformin and can be labeled in situ by means of click chemistry. Firstly, we found this molecule to be more potent than metformin in several cancer cell models. Secondly, this...

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PMID: 30399175
DOI: 10.1371/journal.pone.0206764

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