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Article

Activation of the integrated stress response is a vulnerability for multidrug-resistant FBXW7-deficient cells.

EMBO molecular medicine - 7 Sept 2022

Sanchez-Burgos Laura, Navarro-González Belén, García-Martín Santiago, Sirozh Oleksandra, Mota-Pino Jorge, Fueyo-Marcos Elena, Tejero Héctor, Antón Marta Elena, Murga Matilde, Al-Shahrour Fátima, Fernandez-Capetillo Oscar

Abstract excerpt

FBXW7 is one of the most frequently mutated tumor suppressors, deficiency of which has been associated with resistance to some anticancer therapies. Through bioinformatics and genome-wide CRISPR screens, we here reveal that FBXW7 deficiency leads to multidrug resistance (MDR). Proteomic analyses found an upregulation of mitochondrial factors as a hallmark of FBXW7 deficiency, which has been previously linked to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35861150
DOI: 10.15252/emmm.202215855
PMCID: PMC9449593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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