The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment.

doi:10.1016/j.neurobiolaging.2015.03.004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment.

Neurobiology of aging - 1 Jun 2015

Laczó Jan, Andel Ross, Vyhnalek Martin, Matoska Vaclav, Kaplan Vojtech, Nedelska Zuzana, Lerch Ondrej, Gazova Ivana, Moffat Scott D, Hort Jakub

Abstract excerpt

The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant. We examined the influence of TOMM40 "523" polymorphism on spatial navigation and its brain structural correlates. Participants were apolipoprotein E (APOE) ε3/ε3 homozygotes with amnestic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebral Cortex

Share to Cognitive Dysfunction

Share to Magnetic Resonance Imaging

Share to Membrane Transport Proteins

Share to Mitochondrial Precursor Protein Import Complex Proteins

Share to Neuropsychological Tests

Share to Risk

Source

Open in PubMed

Identifiers

PMID: 25862420
DOI: 10.1016/j.neurobiolaging.2015.03.004

Genes

TOMM40
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment.PMID 25862420Read ↗

Spatial navigation and APOE in amnestic mild cognitive impairment.Semantic proximity Read ↗

TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype.Semantic proximity Read ↗

A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.Semantic proximity Read ↗

The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype.Semantic proximity Read ↗

Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936.Semantic proximity Read ↗

Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes.Semantic proximity Read ↗

No effects of APOE ε4 on spatial navigation and broader cognition in young adults genetically at risk for Alzheimer’s diseaseSemantic proximity Read ↗

TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity.Semantic proximity Read ↗

The influence of APOE and TOMM40 polymorphisms on hippocampal volume and episodic memory in old ageSemantic proximity Read ↗

Hippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE ε4 variant.Semantic proximity Read ↗

TOMM40 '523 Genotype Distinguishes Patterns of Cognitive Improvement for Executive Function in APOEɛ3 Homozygotes.Semantic proximity Read ↗

Longitudinal modeling of cognitive aging and the TOMM40 effect.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.