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The influence of APOE and TOMM40 polymorphisms on hippocampal volume and episodic memory in old age

1 Jan 2013

Abstract excerpt

Mitochondrial dysfunction is implicated in neurodegenerative disorders, such as Alzheimer's disease (AD). Translocase of outer mitochondrial membrane 40 (TOMM40) may be influential in this regard by influencing mitochondrial neurotoxicity. Little is known about the influence of the TOMM40 gene on hippocampal (HC) volume and episodic memory (EM), particularly in healthy older adults. Thus, we sought to discern the...

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PMID: 23734114
DOI: 10.3389/fnhum.2013.00198

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