Article
The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2011
Johnson Sterling C, La Rue Asenath, Hermann Bruce P, Xu Guofan, Koscik Rebecca L, Jonaitis Erin M, Bendlin Barbara B, Hogan Kirk J, Roses Allen D, Saunders Ann M, Lutz Michael W, Asthana Sanjay, Green Robert C, Sager Mark A
Abstract excerpt
OBJECTIVE: Apolipoprotein E (APOE) genotypes are associated with variable risk of developing late-onset Alzheimer's disease (LOAD), with APOE epsilon 4 (APOE ε4) having higher risk. A variable poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated...
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