TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype.

doi:10.1212/WNL.0000000000003614

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Article

TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype.

Neurology - 14 Feb 2017

Yu Lei, Lutz Michael W, Wilson Robert S, Burns Daniel K, Roses Allen D, Saunders Ann M, Gaiteri Chris, De Jager Philip L, Barnes Lisa L, Bennett David A

Abstract excerpt

OBJECTIVE: To interrogate a poly-T variant (rs10524523, '523) in TOMM40, a gene adjacent to the APOE gene on chromosome 19, in older persons with APOE ε3/3 homozygosity for association with cognitive decline, the clinical hallmark of Alzheimer disease (AD). METHODS: Data came from participants in 2 cohort studies of aging and dementia who underwent annual clinical evaluations for up to 21 years. APOE and...

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Identifiers

PMID: 28108637
DOI: 10.1212/WNL.0000000000003614
PMCID: PMC5317377

Genes

APOE
TOMM40

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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