Article

No effects of APOE ε4 on spatial navigation and broader cognition in young adults genetically at risk for Alzheimer’s disease

2026-07-15

Abstract excerpt

Alzheimer’s disease (AD) causes progressive memory loss and disorientation. It is preceded by a prolonged preclinical phase marked by pathological changes in medial temporal lobe regions involved in spatial navigation. Spatial navigation tasks have been proposed for early AD detection, and altered navigation performance was reported in older carriers of the apolipoprotein E (APOE) ε4 allele, the major genetic risk...

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Literature Corpus work: 3b0cfbe2-3e6f-53ac-b159-d7282181543c
DOI: 10.64898/2026.07.10.737269

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