Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936.

doi:10.1016/j.neurobiolaging.2014.01.006

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Article

Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936.

Neurobiology of aging - 1 Jun 2014

Lyall Donald M, Harris Sarah E, Bastin Mark E, Muñoz Maniega Susana, Murray Catherine, Lutz Michael W, Saunders Ann M, Roses Allen D, Valdés Hernández Maria del C, Royle Natalie A, Starr John M, Porteous David J, Wardlaw Joanna M, Deary Ian J

Abstract excerpt

Apolipoprotein E (APOE) ε genotype has previously been significantly associated with cognitive, brain imaging, and Alzheimer's disease-related phenotypes (e.g., age of onset). In the TOMM40 gene, the rs10524523 ("523") variable length poly-T repeat polymorphism has more recently been associated with similar ph/enotypes, although the allelic directions of these associations have varied between initial reports....

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PMID: 24508314
DOI: 10.1016/j.neurobiolaging.2014.01.006
PMCID: PMC3969262

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APOE
TOMM40

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