Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes.

doi:10.1016/j.neurobiolaging.2023.09.001

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Article

Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes.

Neurobiology of aging - 1 Dec 2023

Honea Robyn A, Hunt Suzanne, Lepping Rebecca J, Vidoni Eric D, Morris Jill K, Watts Amber, Michaelis Elias, Burns Jeffrey M, Swerdlow Russell H

Abstract excerpt

Both the APOE ε4 and TOMM40 rs10524523 ("523") genes have been associated with risk for Alzheimer's disease (AD) and neuroimaging biomarkers of AD. No studies have investigated the relationship of TOMM40'523-APOE ε4 on the structural complexity of the brain in AD individuals. We quantified brain morphology and multiple cortical attributes in individuals with mild cognitive impairment (MCI) and AD, then tested...

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PMID: 37804609
DOI: 10.1016/j.neurobiolaging.2023.09.001
PMCID: PMC10763175

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