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Article

Hippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE ε4 variant.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2017

Burggren Alison C, Mahmood Zanjbeel, Harrison Theresa M, Siddarth Prabha, Miller Karen J, Small Gary W, Merrill David A, Bookheimer Susan Y

Abstract excerpt

INTRODUCTION: The translocase of outer mitochondrial membrane 40 (TOMM40), which lies in linkage disequilibrium with apolipoprotein E (APOE), has received attention more recently as a promising gene in Alzheimer's disease (AD) risk. TOMM40 influences AD pathology through mitochondrial neurotoxicity, and the medial temporal lobe (MTL) is the most likely brain region for identifying early manifestations of...

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Source

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Identifiers

PMID: 28183529
DOI: 10.1016/j.jalz.2016.12.009
PMCID: PMC5496778

Genes

TOMM40
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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