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Article

Longitudinal modeling of cognitive aging and the TOMM40 effect.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2012

Caselli Richard J, Dueck Amylou C, Huentelman Matthew J, Lutz Michael W, Saunders Ann M, Reiman Eric M, Roses Allen D

Abstract excerpt

BACKGROUND: TOMM40 (translocase of the outer mitochondrial membrane pore subunit) is in linkage disequilibrium with apolipoprotein E (APOE). APOE e4 is linked to long (L; 21-29 T residues) poly-T variants within intron 6 of TOMM40, whereas APOE e3 can be associated with either a short (S; <21 T residues) or very long (VL; >29 T residues) variant. To assess the possible contribution of TOMM40 to Alzheimer's...

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Source

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Identifiers

PMID: 23102119
DOI: 10.1016/j.jalz.2011.11.006
PMCID: PMC3483561

Genes

TOMM40
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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