TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity.

doi:10.3233/JAD-2011-110743

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Article

TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Maruszak Aleksandra, Pepłońska Beata, Safranow Krzysztof, Chodakowska-Żebrowska Małgorzata, Barcikowska Maria, Zekanowski Cezary

Abstract excerpt

Recently, it has been reported that TOMM40 variable-length poly-T sequence polymorphism (rs10524523) in combination with APOE alleles (E2, E3, E4) significantly influences late-onset Alzheimer's disease (LOAD) age of onset. In a group of 414 LOAD patients, 173 centenarians and 305 neurologically healthy individuals, we investigated the impact of TOMM40 poly-T tracts on LOAD incidence, age of onset, and longevity....

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Identifiers

PMID: 22008263
DOI: 10.3233/JAD-2011-110743

Genes

TOMM40
APOE

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