A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.

doi:10.1016/j.jalz.2011.10.005

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Article

A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2012

Hayden Kathleen M, McEvoy Jill M, Linnertz Colton, Attix Deborah, Kuchibhatla Maragatha, Saunders Ann M, Lutz Michael W, Welsh-Bohmer Kathleen A, Roses Allen D, Chiba-Falek Ornit

Abstract excerpt

INTRODUCTION: A highly polymorphic T homopolymer was recently found to be associated with late-onset Alzheimer's disease risk and age of onset. OBJECTIVE: To explore the effects of the polymorphic polyT tract (rs10524523, referred as '523') on cognitive performance in cognitively healthy elderly individuals. METHODS: One hundred eighty-one participants were recruited from local independent-living retirement...

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Identifiers

PMID: 22863908
DOI: 10.1016/j.jalz.2011.10.005
PMCID: PMC3438346

Genes

APOE
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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