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Article

Testing for polygenic effects in genome-wide association studies.

Genetic epidemiology - 1 May 2015

Pan Wei, Chen Yue-Ming, Wei Peng

Abstract excerpt

To confirm associations with a large number of single nucleotide polymorphisms (SNPs), each with only a small effect size, as hypothesized in the polygenic theory for schizophrenia, the International Schizophrenia Consortium (2009, Nature 460:748-752) proposed a polygenic risk score (PRS) test and demonstrated its effectiveness when applied to psychiatric disorders. The basic idea of the PRS test is to use a half...

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Identifiers

PMID: 25847094
DOI: 10.1002/gepi.21899
PMCID: PMC4406854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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