Article

Improving Polygenic Prediction in Ancestrally Diverse Populations

2021-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) were predominantly conducted in individuals of European descent, the limited transferability of PRS reduces its clinical value in non-European populations and may exacerbate healthcare disparities. Recent efforts to level ancestry imbalance in genomic research h...

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Literature Corpus work: 05fffb28-32b6-5150-984a-caa43c90b793
DOI: 10.1101/2020.12.27.20248738

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