Article
Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores.
Nature genetics - 1 Oct 2023
Campos Adrian I, Namba Shinichi, Lin Shu-Chin, Nam Kisung, Sidorenko Julia, Wang Huanwei, Kamatani Yoichiro, Wang Ling-Hua, Lee Seunggeun, Lin Yen-Feng, Feng Yen-Chen Anne, Okada Yukinori, Visscher Peter M, Yengo Loic
Abstract excerpt
Genome-wide association studies (GWASs) have been mostly conducted in populations of European ancestry, which currently limits the transferability of their findings to other populations. Here, we show, through theory, simulations and applications to real data, that adjustment of GWAS analyses for polygenic scores (PGSs) increases the statistical power for discovery across all ancestries. We applied this method to...
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