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Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype?

International review of psychiatry (Abingdon, England) - 1 Jan 2000

Fusar-Poli Laura, Rutten Bart P F, van Os Jim, Aguglia Eugenio, Guloksuz Sinan

Abstract excerpt

Over the last years, the decreased costs and enhanced accessibility to large genome-wide association studies datasets have laid the foundations for the development of polygenic risk scores (PRSs). A PRS is calculated on the weighted sum of single nucleotide polymorphisms and measures the individual genetic predisposition to develop a certain phenotype. An increasing number of studies have attempted to utilize the...

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PMID: 36786114
DOI: 10.1080/09540261.2022.2101352

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