Article
Improving polygenic prediction in ancestrally diverse populations.
Nature genetics - 1 May 2022
Ruan Yunfeng, Lin Yen-Feng, Feng Yen-Chen Anne, Chen Chia-Yen, Lam Max, Guo Zhenglin, He Lin, Sawa Akira, Martin Alicia R, Qin Shengying, Huang Hailiang, Ge Tian
Abstract excerpt
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) have been conducted predominantly in individuals of European descent, the limited transferability of PRS reduces their clinical value in non-European populations, and may exacerbate healthcare disparities. Recent efforts to level ancestry imbalance in genomic research have...
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