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Article

A powerful and adaptive association test for rare variants.

Genetics - 1 Aug 2014

Pan Wei, Kim Junghi, Zhang Yiwei, Shen Xiaotong, Wei Peng

Abstract excerpt

This article focuses on conducting global testing for association between a binary trait and a set of rare variants (RVs), although its application can be much broader to other types of traits, common variants (CVs), and gene set or pathway analysis. We show that many of the existing tests have deteriorating performance in the presence of many nonassociated RVs: their power can dramatically drop as the proportion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24831820
DOI: 10.1534/genetics.114.165035
PMCID: PMC4125385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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