A gene based combination test using GWAS summary data.

doi:10.1186/s12859-022-05114-x

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Article

A gene based combination test using GWAS summary data.

BMC bioinformatics - 3 Jan 2023

Zhang Jianjun, Liang Xiaoyu, Gonzales Samantha, Liu Jianguo, Gao Xiaoyi Raymond, Wang Xuexia

Abstract excerpt

BACKGROUND: Gene-based association tests provide a useful alternative and complement to the usual single marker association tests, especially in genome-wide association studies (GWAS). The way of weighting for variants in a gene plays an important role in boosting the power of a gene-based association test. Appropriate weights can boost statistical power, especially when detecting genetic variants with weak...

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PMID: 36597047
DOI: 10.1186/s12859-022-05114-x
PMCID: PMC9811798

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