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Article

Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.

Annual review of clinical psychology - 7 May 2018

Bogdan Ryan, Baranger David A A, Agrawal Arpana

Abstract excerpt

Genomewide association studies (GWASs) across psychiatric phenotypes have shown that common genetic variants generally confer risk with small effect sizes (odds ratio < 1.1) that additively contribute to polygenic risk. Summary statistics derived from large discovery GWASs can be used to generate polygenic risk scores (PRS) in independent, target data sets to examine correlates of polygenic disorder liability...

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Identifiers

PMID: 29579395
DOI: 10.1146/annurev-clinpsy-050817-084847
PMCID: PMC7772939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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