Article

Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans

2022-01-19

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) in admixed populations such as African American (AA) have limited sample sizes, resulting poor performance of polygenic risk scores (PRS). Based on the observations that many disease-causing genes are shared between AA and European ancestry (EA) populations, and some disease-causing variants are located within boundaries of these genes, we proposed a novel g...

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Literature Corpus work: 4bc2344c-5668-5977-ba84-475b3125d5c5
DOI: 10.1101/2022.01.19.22269532

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