Article

Improving Polygenic Prediction in Ancestrally Diverse Populations

2021-01-06

Abstract excerpt

<title>Abstract</title> <p>Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) were predominantly conducted in individuals of European descent, the limited transferability of PRS reduces its clinical value in non-European populations and may exacerbate healthcare disparities. Recent efforts to level ancestry imbalance in genomic r...

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Literature Corpus work: 4c0887e7-e3e3-5606-a62f-8e2b110a3bd4
DOI: 10.21203/rs.3.rs-133290/v1

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