Article
Plasticity of empty major histocompatibility complex class I molecules determines peptide-selector function.
Molecular immunology - 1 Dec 2015
van Hateren Andy, Bailey Alistair, Werner Jörn M, Elliott Tim
Abstract excerpt
Major histocompatibility complex class I (MHC I) proteins provide protection from intracellular pathogens and cancer via each of a cell's MHC I molecules binding and presenting a peptide to cytotoxic T lymphocytes. MHC I genes are highly polymorphic and can have significant diversity, with polymorphisms predominantly localised in the peptide-binding groove where they can change peptide-binding specificity....
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