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Article

Selector function of MHC I molecules is determined by protein plasticity.

Scientific reports - 20 Oct 2015

Bailey Alistair, Dalchau Neil, Carter Rachel, Emmott Stephen, Phillips Andrew, Werner Jörn M, Elliott Tim

Abstract excerpt

The selection of peptides for presentation at the surface of most nucleated cells by major histocompatibility complex class I molecules (MHC I) is crucial to the immune response in vertebrates. However, the mechanisms of the rapid selection of high affinity peptides by MHC I from amongst thousands of mostly low affinity peptides are not well understood. We developed computational systems models encoding distinct...

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Share to Antigen Presentation
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Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26482009
DOI: 10.1038/srep14928
PMCID: PMC5224517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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