Article

Sequence-structure-function relationships in class I MHC: a local frustration perspective

2019-12-06

Abstract excerpt

Class I Major Histocompatibility Complex (MHC) binds short antigenic peptides with the help of Peptide Loading Complex (PLC), and presents them to T-cell Receptors (TCRs) of cytotoxic T-cells and Killer-cell Immunglobulin-like Receptors (KIRs) of Natural Killer (NK) cells. With more than 10000 alleles, the Human Leukocyte Antigen (HLA) chain of MHC is the most polymorphic protein in humans. This allelic diversity...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f88b4637-6946-5b88-b67c-0046d36f223d
DOI: 10.1101/867473

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sequence-structure-function relationships in class I MHC: a local frustration perspectiveDOI 10.1101/867473Read

Sequence-structure-function relationships in class I MHC: A local frustration perspective.Semantic proximity Read

Compression of functional space in HLA-A sequence diversity.Semantic proximity Read

A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens.Semantic proximity Read

Machine learning reveals a non-canonical mode of peptide binding to MHC class II molecules.Semantic proximity Read

Conserved Biophysical Compatibility Among the Highly Variable Germline-Encoded Regions Shapes TCR-MHC InteractionsSemantic proximity Read

Sequence variability analysis of human class I and class II MHC molecules: functional and structural correlates of amino acid polymorphisms.Semantic proximity Read

CDR3 binding chemistry controls TCR V-domain rotational probability and germline CDR2 scanning of polymorphic MHCSemantic proximity Read

A practical guide to structure-based prediction of MHC-binding peptides.Semantic proximity Read

Mapping the Peptide Interaction Fingerprint of the Behçet’s disease associated HLA-B*51Semantic proximity Read

Computational characterization of residue couplings and micropolymorphism-induced changes in the dynamics of two differentially disease-associated human MHC class-I alleles.Semantic proximity Read

Somatic genetics of CDR3 control TCR V-domain rotational probability and germline CDR2 scanning of polymorphic MHCSemantic proximity Read

Structural properties of MHC class II ligands, implications for the prediction of MHC class II epitopes.Semantic proximity Read