Article

Variations in MHC class I antigen presentation and immunopeptidome selection pathways

2020-09-28

Abstract excerpt

Major histocompatibility class I (MHC-I) proteins mediate immunosurveillance against pathogens and cancers by presenting antigenic or mutated peptides to antigen receptors of CD8+ T cells and by engaging receptors of natural killer (NK) cells. In humans, MHC-I molecules are highly polymorphic. MHC-I variations permit the display of thousands of distinct peptides at the cell surface. Recent mass spectrometric studi...

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Literature Corpus work: d4e3de39-2a34-5192-8e22-ac4e0761ce92
DOI: 10.12688/f1000research.26935.1

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