Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Open MHC Class I Conformers: A Look through the Looking Glass.

International journal of molecular sciences - 8 Sept 2021

Arosa Fernando A, Esgalhado André J, Reste-Ferreira Débora, Cardoso Elsa M

Abstract excerpt

Studies carried out during the last few decades have consistently shown that cell surface MHC class I (MHC-I) molecules are endowed with functions unrelated with antigen presentation. These include cis-trans-interactions with inhibitory and activating KIR and LILR, and cis-interactions with receptors for hormones, growth factors, cytokines, and neurotransmitters. The mounting body of evidence indicates that these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histocompatibility Antigens Class I
Share to Immunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunomodulation

Share to Protein Binding

Share to Protein Conformation

Share to Protein Multimerization

Share to Signal Transduction

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 34575902
DOI: 10.3390/ijms22189738
PMCID: PMC8470049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Open MHC Class I Conformers: A Look through the Looking Glass.PMID 34575902Read ↗

Immunological Functions of the Membrane Proximal Region of MHC Class II MoleculesSemantic proximity Read ↗

Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypesSemantic proximity Read ↗

Plasticity of empty major histocompatibility complex class I molecules determines peptide-selector function.Semantic proximity Read ↗

Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.Semantic proximity Read ↗

Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptorSemantic proximity Read ↗

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligandsSemantic proximity Read ↗

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometrySemantic proximity Read ↗

Machine learning reveals a non-canonical mode of peptide binding to MHC class II molecules.Semantic proximity Read ↗

Molecular Determinants Regulating the Plasticity of the MHC Class II ImmunopeptidomeSemantic proximity Read ↗

Unconventional Peptide Presentation by Major Histocompatibility Complex (MHC) Class I Allele HLA-A*02:01: BREAKING CONFINEMENT.Semantic proximity Read ↗

Design of solubly expressed miniaturized SMART MHCsSemantic proximity Read ↗

MHC class I-peptide interactions and TCR recognition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.