Article

Immunological Functions of the Membrane Proximal Region of MHC Class II Molecules

2016-03-17

Abstract excerpt

Major histocompatibility complex (MHC) class II molecules present exogenously derived antigen peptides to CD4 T cells, driving activation of naïve T cells and supporting CD4-driven immune functions. However, MHC class II molecules are not inert protein pedestals that simply bind and present peptides. These molecules also serve as multi-functional signaling molecules delivering activation, differentiation, or death...

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Literature Corpus work: 9e000ca6-c3d8-5acc-8691-e6a74f06d3c5
DOI: 10.12688/f1000research.7610.1

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