Article

HLA binding of self-peptides is biased towards proteins with specific molecular functions

2021-02-17

Abstract excerpt

Human leukocyte antigen (HLA) is highly polymorphic and plays a key role in guiding adaptive immune responses by presenting foreign and self peptides to T cells. Each HLA variant selects a minor fraction of peptides that match a certain motif required for optimal interaction with the peptide-binding groove. These restriction rules define the landscape of peptides presented to T cells. Given these limitations, one...

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Literature Corpus work: 9f3acc33-f70b-5181-a47a-5d129e8c0ed3
DOI: 10.1101/2021.02.16.431395

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