Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule.

doi:10.1038/357211a0

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Article

Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule.

Nature - 21 May 1992

Powis S J, Deverson E V, Coadwell W J, Ciruela A, Huskisson N S, Smith H, Butcher G W, Howard J C

Abstract excerpt

Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polymorphism in one of the major histocompatibility complex-encoded putative peptide-transporter genes is associated with...

Topics

Alleles
Amino Acid Sequence
Animals
Carrier Proteins
Cell Line
Genes, MHC Class I
Histocompatibility Antigens Class I
Humans
Kinetics
Lymphoma, T-Cell
Major Histocompatibility Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Membrane Transport Proteins

Molecular Sequence Data

Poly A

Polymerase Chain Reaction

Polymorphism, Genetic

Protein Conformation

Source

Open in PubMed

Identifiers

PMID: 1350326
DOI: 10.1038/357211a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1350326-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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