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Article

Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules.

Nature communications - 9 Jul 2021

Lan Huan, Abualrous Esam T, Sticht Jana, Fernandez Laura Maria Arroyo, Werk Tamina, Weise Christoph, Ballaschk Martin, Schmieder Peter, Loll Bernhard, Freund Christian

Abstract excerpt

The repertoire of peptides presented by major histocompatibility complex class I (MHC-I) molecules on the cell surface is tailored by the ER-resident peptide loading complex (PLC), which contains the exchange catalyst tapasin. Tapasin stabilizes MHC-I molecules and promotes the formation of stable peptide-MHC-I (pMHC-I) complexes that serve as T cell antigens. Exchange of suboptimal by high-affinity ligands is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34244493
DOI: 10.1038/s41467-021-24401-4
PMCID: PMC8271027

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