Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotoxicity assessment of melamine in the in vivo Pig-a mutation assay and in a standard battery of assays.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2015

Tu Honggang, Zhang Ming, Zhou Changhui, Wang Zheng, Huang Pengcheng, Ou Hongmei, Chang Yan

Abstract excerpt

The genotoxicity of melamine was evaluated with the combined Pig-a mutation/micronucleus assay, the bacterial reverse mutation assay, and the in vitro cytokinesis-block micronucleus assay (CBMN). Five groups of six- to eight-week-old male Sprague-Dawley (SD) rats were given three daily doses of vehicle control (100% pure sesame oil), melamine (500, 1000, and 2000 mg/kg) or positive control (N-ethyl-N-nitrosourea,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral
Share to CD59 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cricetulus

Share to Ethylnitrosourea

Share to Micronucleus Tests

Share to Reticulocytes

Share to Salmonella typhimurium

Share to Triazines

Source

Identifiers

PMID: 25726176
DOI: 10.1016/j.mrgentox.2014.12.001

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotoxicity assessment of melamine in the in vivo Pig-a mutation assay and in a standard battery of assays.PMID 25726176Read ↗

Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.Semantic proximity Read ↗

Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.Semantic proximity Read ↗

Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.Semantic proximity Read ↗

In vivo pig-a and micronucleus study of the prototypical aneugen vinblastine sulfate.Semantic proximity Read ↗

International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea.Semantic proximity Read ↗

Multi-laboratory evaluation of 1,3-propane sultone, N-propyl-N-nitrosourea, and mitomycin C in the Pig-a mutation assay in vivo.Semantic proximity Read ↗

Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.Semantic proximity Read ↗

Continued progress in developing the Pig-a gene mutation assay.Semantic proximity Read ↗

[Optimization ofPig-aGene Mutation in Rats and Assessment of Time-dependent and Dose-response Relationship of N-ethyl-N-nitrosourea].Semantic proximity Read ↗

[Genotoxicity assessment of 2-ethylhexyl acrylate using an in vivo Pig-a gene mutation assay integrated system].Semantic proximity Read ↗

Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate.Semantic proximity Read ↗

Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.