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International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea.

Environmental and molecular mutagenesis - 1 Dec 2011

Lynch Anthony M, Giddings Amanda, Custer Laura, Gleason Carol, Henwood Andrew, Aylott Mike, Kenny Julia

Abstract excerpt

N-methyl-N-nitrosourea (MNU) was evaluated in the in vivo Pig-a mutation assay as part of an International Collaborative Trial to investigate laboratory reproducibility, 28-day study integration, and comparative analysis with micronucleus (MN), comet, and clinical pathology endpoints. Male Sprague Dawley rats were treated for 28 days with doses of 0, 2.5, 5, and 10 mg MNU/kg/day in two independent laboratories,...

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PMID: 22167885
DOI: 10.1002/em.20691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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