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Multi-laboratory evaluation of 1,3-propane sultone, N-propyl-N-nitrosourea, and mitomycin C in the Pig-a mutation assay in vivo.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jul 2018

Chung Young-Shin, Pak Bumsoo, Han Sehee, Lee Jiyeon, Kim Jiyoung, Back Seng-Min, Park Cho-Rong, Kim Su-Hwan, Lee Jong-Kwon

Abstract excerpt

The mutagenic potencies of 1,3-propane sultone (PS), N-propyl-N-nitrosourea (PNU), and mitomycin C (MMC) were investigated in three independent laboratories in Korea using the Pig-a assay in vivo. Sprague-Dawley rats were treated with vehicle or test substance on three consecutive days. Blood samples were collected for measuring Pig-a mutant phenotypes (CD59-deficient erythrocytes, RBCCD59-; CD59-deficient...

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PMID: 29875078
DOI: 10.1016/j.mrgentox.2018.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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