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Article

In vivo pig-a and micronucleus study of the prototypical aneugen vinblastine sulfate.

Environmental and molecular mutagenesis - 1 Jan 2018

Avlasevich Svetlana L, Labash Carson, Torous Dorothea K, Bemis Jeffrey C, MacGregor James T, Dertinger Stephen D

Abstract excerpt

The Pig-a assay is being used in regulatory studies to evaluate the potential of agents to induce somatic cell gene mutations and an OECD test guideline is under development. A working group involved with establishing the guideline recently noted that representative aneugenic agents had not been evaluated, and to help fill this data gap Pig-a mutant phenotype and micronucleated reticulocyte frequencies were...

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Identifiers

PMID: 28833575
DOI: 10.1002/em.22122
PMCID: PMC5773054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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