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Article

Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 2012

Dertinger Stephen D, Phonethepswath Souk, Avlasevich Svetlana L, Torous Dorothea K, Mereness Jared, Bryce Steven M, Bemis Jeffrey C, Bell Sara, Weller Pamela, Macgregor James T

Abstract excerpt

The ability to effectively monitor gene mutation and micronucleated reticulocyte (MN-RET) frequency in short-term and repeated dosing schedules was investigated using the recently developed flow cytometric Pig-a mutation assay and flow cytometric micronucleus analysis. Eight reference genotoxicants and three presumed nongenotoxic compounds were studied: chlorambucil, melphalan, thiotepa, cyclophosphamide,...

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Identifiers

PMID: 22923490
DOI: 10.1093/toxsci/kfs258
PMCID: PMC3498746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.PMID 22923490Read ↗

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