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Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.

Environmental and molecular mutagenesis - 1 Dec 2011

Cammerer Zoryana, Bhalli Javed A, Cao Xuefei, Coffing Stephanie L, Dickinson Donna, Dobo Krista L, Dobrovolsky Vasily N, Engel Maria, Fiedler Ronald D, Gunther William C, Heflich Robert H, Pearce Mason G, Shaddock Joseph G, Shutsky Thomas, Thiffeault Catherine J, Schuler Maik

Abstract excerpt

N-Ethyl-N-nitrosourea (ENU) was evaluated as part of the Stage III trial for the rat Pig-a gene mutation assay. Groups of six- to eight-week-old male Sprague Dawley (SD) or Fischer 344 (F344) rats were given 28 daily doses of the phosphate buffered saline vehicle, or 2.5, 5, or 10 mg/kg ENU, and evaluated for a variety of genotoxicity endpoints in peripheral blood, spleen, liver, and colon. Blood was sampled...

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PMID: 22167886
DOI: 10.1002/em.20686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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