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Continued progress in developing the Pig-a gene mutation assay.

Mutagenesis - 1 May 2015

Heflich Robert H, Dobrovolsky Vasily N, Dertinger Stephen D

Abstract excerpt

The Pig-a assay has shown promise as a regulatory assay for evaluating in vivo gene mutation. A recent International Workshop on Genotoxicity Testing workgroup discussed the state of the assay and identified several knowledge gaps in assay development. This Mutagenesis Special Topic includes a collection of reports that addresses some of these knowledge gaps, including identifying the mutations responsible for...

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PMID: 25934984
DOI: 10.1093/mutage/geu082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Continued progress in developing the Pig-a gene mutation assay.PMID 25934984Read ↗

The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review.Semantic proximity Read ↗

In vitro mammalian cell mutation assays based on the Pig-a gene: A report of the 7th International Workshop on Genotoxicity Testing (IWGT) Workgroup.Semantic proximity Read ↗

The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: Summary of the MMS/JEMS-collaborative study across 16 laboratories using 24 chemicals.Semantic proximity Read ↗

In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene.Semantic proximity Read ↗

Report on stage III Pig-a mutation assays using benzo[a]pyrene.Semantic proximity Read ↗

The IWGT in vitro Mammalian Cell Gene Mutation (MCGM) assays working group-Introductory remarks & consensus statements.Semantic proximity Read ↗

PIG-A gene mutation as a genotoxicity biomarker in human population studies: An investigation in lead-exposed workers.Semantic proximity Read ↗

Development of an in vitro PIG-A gene mutation assay in human cells.Semantic proximity Read ↗

Detection of Pig-a gene mutants in rat peripheral blood following a single urethane treatment: A comparison of the RBC Pig-a and PIGRET assays.Semantic proximity Read ↗

Erythrocyte-based Pig-a gene mutation assay.Semantic proximity Read ↗

Characterisation of an in vivo Pig-a gene mutation assay for use in regulatory toxicology studies.Semantic proximity Read ↗

The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup.Semantic proximity Read ↗

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