Article
Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.
Environmental and molecular mutagenesis - 1 May 2014
Dertinger Stephen D, Phonethepswath Souk, Avlasevich Svetlana L, Torous Dorothea K, Mereness Jared, Cottom John, Bemis Jeffrey C, Macgregor James T
Abstract excerpt
To evaluate whether blood-based genotoxicity endpoints can provide temporal and dose-response data within the low-dose carcinogenic range that could contribute to carcinogenic mode of action (MoA) assessments, we evaluated the sensitivity of flow cytometry-based micronucleus and Pig-a gene mutation assays at and below tumorigenic dose rate 50 (TD50) levels. The incidence of micronucleated reticulocytes (MN-RET)...
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