Article
Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays.
Regulatory toxicology and pharmacology : RTP - 1 Jun 2023
Li Xilin, Le Yuan, Seo Ji-Eun, Guo Xiaoqing, Li Yuxi, Chen Si, Mittelstaedt Roberta A, Moore Nyosha, Guerrero Sharon, Sims Audrey, King Sruthi T, Atrakchi Aisar H, McGovern Timothy J, Davis-Bruno Karen L, Keire David A, Elespuru Rosalie K, Heflich Robert H, Mei Nan
Abstract excerpt
Propranolol is a widely used β-blocker that can generate a nitrosated derivative, N-nitroso propranolol (NNP). NNP has been reported to be negative in the bacterial reverse mutation test (the Ames test) but genotoxic in other in vitro assays. In the current study, we systematically examined the in vitro mutagenicity and genotoxicity of NNP using several modifications of the Ames test known to affect the...
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