Article
Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.
Environmental and molecular mutagenesis - 1 Dec 2014
Zhou Changhui, Zhang Min, Huang Pengcheng, Tu Honggang, Wang Zheng, Dertinger Stephen D, Torous Dorothea K, Chang Yan
Abstract excerpt
Genotoxicity assessments were conducted on male Sprague Dawley rats treated with 5-fluorouracil (5-FU) and 4-nitroquinoline-1-oxide (4NQO) as part of an international validation trial of the Pig-a mutant phenotype assay. Rats were orally exposed to 0, 11.5, 23, or 46 mg/kg/day 5-FU for three consecutive days (Days 1-3); blood was sampled on Days -1, 4, 15, 29, and 45. Pig-a mutant phenotype reticulocyte...
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