Article
Dominance genetic variation contributes little to the missing heritability for human complex traits.
American journal of human genetics - 5 Mar 2015
Zhu Zhihong, Bakshi Andrew, Vinkhuyzen Anna A E, Hemani Gibran, Lee Sang Hong, Nolte Ilja M, van Vliet-Ostaptchouk Jana V, Snieder Harold, Esko Tonu, Milani Lili, Mägi Reedik, Metspalu Andres, Hill William G, Weir Bruce S, Goddard Michael E, Visscher Peter M, Yang Jian
Abstract excerpt
For human complex traits, non-additive genetic variation has been invoked to explain "missing heritability," but its discovery is often neglected in genome-wide association studies. Here we propose a method of using SNP data to partition and estimate the proportion of phenotypic variance attributed to additive and dominance genetic variation at all SNPs (hSNP(2) and δSNP(2)) in unrelated individuals based on an...
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