Article

Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selection

2018-06-27

Abstract excerpt

The genetic architecture of most human complex traits is highly polygenic, motivating efforts to detect polygenic selection involving a large number of loci. In contrast to previous work relying on top GWAS loci, we developed a method that uses genome-wide association statistics and linkage disequilibrium patterns to estimate the genome-wide genetic component of population differentiation of a complex trait along...

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Literature Corpus work: 86423ded-bc1b-5396-a68a-a4abbc976b46
DOI: 10.1101/357483

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