Back to search

Article

A Two-State Epistasis Model Reduces Missing Heritability of Complex Traits

2015-04-08

Abstract excerpt

<h4>ABSTRACT</h4> Despite decade-long efforts, the genetic underpinnings of many complex traits and diseases remain largely elusive. It is increasingly recognized that a purely additive model, upon which most genome-wide association studies (GWAS) rely, is insufficient. Although thousands of significant trait-associated loci have been identified, purely additive models leave much of the inferred genetic variance...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6e520a0c-c857-5dad-9563-52704bd3efe8
DOI
10.1101/017491
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Two-State Epistasis Model Reduces Missing Heritability of Complex TraitsDOI 10.1101/017491
Finding the Sources of Missing Heritability Using the Additive Epistatic Interaction Model: A Simulation StudySemantic proximity
Understanding the genetic risks of complex diseases using the additive epistatic interaction model: a simulation studySemantic proximity
A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasisSemantic proximity
Two-Stage Testing for Epistasis: Screening and Verification.Semantic proximity
Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits.Semantic proximity
Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals.Semantic proximity
A perspective on epistasis: limits of models displaying no main effect.Semantic proximity
Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individualsSemantic proximity
Detecting Epistasis with the Marginal Epistasis Test in Genetic Mapping Studies of Quantitative TraitsSemantic proximity
Discovering non-additive heritability using additive GWAS summary statistics.Semantic proximity
Finding the missing heritability of complex diseases.Semantic proximity
Detecting epistasis in human complex traits.Semantic proximity
Select a neighboring publication to make it the new centre.