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Article

Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits.

PLoS genetics - 1 May 2013

Zaitlen Noah, Kraft Peter, Patterson Nick, Pasaniuc Bogdan, Bhatia Gaurav, Pollack Samuela, Price Alkes L

Abstract excerpt

Important knowledge about the determinants of complex human phenotypes can be obtained from the estimation of heritability, the fraction of phenotypic variation in a population that is determined by genetic factors. Here, we make use of extensive phenotype data in Iceland, long-range phased genotypes, and a population-wide genealogical database to examine the heritability of 11 quantitative and 12 dichotomous...

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Identifiers

PMID: 23737753
DOI: 10.1371/journal.pgen.1003520
PMCID: PMC3667752

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