Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dominant Genetic Variation and Missing Heritability for Human Complex Traits: Insights from Twin versus Genome-wide Common SNP Models.

American journal of human genetics - 5 Nov 2015

Chen Xu, Kuja-Halkola Ralf, Rahman Iffat, Arpegård Johannes, Viktorin Alexander, Karlsson Robert, Hägg Sara, Svensson Per, Pedersen Nancy L, Magnusson Patrik K E

Abstract excerpt

In order to further illuminate the potential role of dominant genetic variation in the "missing heritability" debate, we investigated the additive (narrow-sense heritability, h(2)) and dominant (δ(2)) genetic variance for 18 human complex traits. Within the same study base (10,682 Swedish twins), we calculated and compared the estimates from classic twin-based structural equation model with SNP-based...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Environment
Share to Genes, Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Models, Genetic

Share to Prognosis

Share to Quantitative Trait, Heritable

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 26544805
DOI: 10.1016/j.ajhg.2015.10.004
PMCID: PMC4667127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dominant Genetic Variation and Missing Heritability for Human Complex Traits: Insights from Twin versus Genome-wide Common SNP Models.PMID 26544805Read ↗

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals.Semantic proximity Read ↗

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individualsSemantic proximity Read ↗

Twins and the mystery of missing heritability: the contribution of gene-environment interactions.Semantic proximity Read ↗

Meta-analysis of the heritability of human traits based on fifty years of twin studies.Semantic proximity Read ↗

Open problems in human trait genetics.Semantic proximity Read ↗

Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study.Semantic proximity Read ↗

Dominance genetic variation contributes little to the missing heritability for human complex traits.Semantic proximity Read ↗

A Two-State Epistasis Model Reduces Missing Heritability of Complex TraitsSemantic proximity Read ↗

Concepts, estimation and interpretation of SNP-based heritability.Semantic proximity Read ↗

On the modelling of variance components in classical twin studies.Semantic proximity Read ↗

Measuring missing heritability: inferring the contribution of common variants.Semantic proximity Read ↗

Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.