Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of genetic dominance in the UK Biobank.

Science (New York, N.Y.) - 31 Mar 2023

Palmer Duncan S, Zhou Wei, Abbott Liam, Wigdor Emilie M, Baya Nikolas, Churchhouse Claire, Seed Cotton, Poterba Tim, King Daniel, Kanai Masahiro, Bloemendal Alex, Neale Benjamin M

Abstract excerpt

Classical statistical genetics theory defines dominance as any deviation from a purely additive, or dosage, effect of a genotype on a trait, which is known as the dominance deviation. Dominance is well documented in plant and animal breeding. Outside of rare monogenic traits, however, evidence in humans is limited. We systematically examined common genetic variation across 1060 traits in a large population cohort...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Specimen Banks
Share to Breeding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Genetic Variation

Share to Models, Genetic

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 36996212
DOI: 10.1126/science.abn8455
PMCID: PMC10345642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of genetic dominance in the UK Biobank.PMID 36996212Read ↗

Analysis of genetic dominance in the UK BiobankSemantic proximity Read ↗

Quantifying the contribution of dominance deviation effects to complex trait variation in biobank-scale data.Semantic proximity Read ↗

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individualsSemantic proximity Read ↗

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals.Semantic proximity Read ↗

Estimating the mode of inheritance in genetic association studies of qualitative traits based on the degree of dominance index.Semantic proximity Read ↗

Phenome-wide Heritability Analysis of the UK BiobankSemantic proximity Read ↗

Sex differences in genetic architecture in the UK Biobank.Semantic proximity Read ↗

Dominance genetic variation contributes little to the missing heritability for human complex traits.Semantic proximity Read ↗

Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygositySemantic proximity Read ↗

Influence of autozygosity on common disease risk across the phenotypic spectrum.Semantic proximity Read ↗

Benefits of Dominance over Additive Models for the Estimation of Average Effects in the Presence of Dominance.Semantic proximity Read ↗

Genetic epidemiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.